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KMID : 1150620190030010011
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Biomedical Dermatology
2019 Volume.3 No. 1 p.11 ~ p.11
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Antioxidants as stabilizers of UV filters: an example for the UV-B filter octylmethoxycinnamate
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Lorigo Margarida
Cairrao Elisa
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Abstract
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Sunlight is one of the main harmful exogenous factors that induce the reactive oxygen species formation. The human skin is the first line of photoprotection against harmful exogenous factors, such as UV radiations. The topical application of sunscreens, containing UV-B filters, is widely used to protect against UV-induced damage. Octylmethoxycinnamate is the world’s most widely used UV-B filter in sunscreens. However, recent studies have demonstrated that this substance is an endocrine disruptor compound and with potential to damage DNA. Thus, the safety of this organic filter is a current concern for human health, and it was urgent to develop new photoprotective strategies. In this sense, due to the potential to neutralize the UV-induced free radicals, the use of antioxidants as UV filter stabilizers presented as a novel promising strategy.
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KEYWORD
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UV radiation, DNA damage, Reactive oxygen species (ROS), Endocrine disruptor compound, Sunscreens, Photoprotection
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Listed journal information
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